6/29/2023 0 Comments Keynote 158 clinical trials.gov![]() ![]() ![]() The study excluded patients with endometrial sarcoma, carcinosarcoma, pre-existing Grade ≥3 fistula, uncontrolled blood pressure (>150/90 mmHg), significant cardiovascular impairment or event within previous 12 months or patients who had active autoimmune disease or a medical condition that required immunosuppression. Participants may have received up to two platinum-containing therapies in total, as long as one was given in the neoadjuvant or adjuvant treatment setting. ![]() KEYNOTE-775/Study 309 (, NCT03517449) is a Phase 3, multicenter, open-label, randomized, active-controlled study conducted in 827 patients with advanced endometrial carcinoma who had been previously treated with at least one prior platinum-based chemotherapy regimen in any setting, including in the neoadjuvant and adjuvant settings. Merck and Eisai are studying the KEYTRUDA plus LENVIMA combination through the LEAP (LEnvatinib And Pembrolizumab) clinical program in more than 10 different tumor types across more than 20 clinical trials. KEYTRUDA plus LENVIMA is also approved in the European Union and Japan for certain patients with advanced or recurrent endometrial carcinoma regardless of mismatch repair status. for patients with advanced endometrial carcinoma that is not microsatellite instability-high or dMMR, who have disease progression following prior systemic therapy in any setting and are not candidates for curative surgery or radiation. The publication contains results for the all-comer population, including the mismatch repair deficient (dMMR) patient population for which KEYTRUDA plus LENVIMA is not approved in the U.S.īased on the results from the Phase 3 KEYNOTE-775/Study 309 trial, KEYTRUDA plus LENVIMA has been approved in the U.S. “The publication of this study in the New England Journal of Medicine reflects the importance of our joint research in exploring the potential of the KEYTRUDA plus LENVIMA combination.” “The Phase 3 KEYNOTE-775/Study 309 trial demonstrates the ongoing commitment that Eisai and Merck share in addressing the unmet needs of people living with difficult-to-treat cancers, including advanced endometrial carcinoma,” said Corina Dutcus, M.D., Senior Vice President, Clinical Research, Oncology Business Group at Eisai Inc. and other countries around the world, where it became the first immunotherapy and tyrosine kinase inhibitor combination approved for these patients.” “KEYNOTE-775/Study 309 is an important Phase 3 study that supported recent approvals of KEYTRUDA plus LENVIMA for certain types of advanced endometrial carcinoma in the U.S. Gregory Lubiniecki, Vice President, Oncology Clinical Research, Merck Research Laboratories. “While rates of endometrial carcinoma continue to rise globally, patients with advanced or recurrent disease have limited options available to them once the disease progresses following platinum-based chemotherapy,” said Dr. Objective response rate (ORR) data and additional detailed efficacy and safety data, including subgroup analyses, are also featured in the publication. Results showed that the KEYTRUDA plus LENVIMA combination demonstrated statistically significant improvements in the dual primary endpoints of overall survival (OS) and progression-free survival (PFS) compared to chemotherapy. The publication includes previously reported data that was first presented in an oral plenary session at the virtual Society of Gynecologic Oncology (SGO) 2021 Annual Meeting on Women’s Cancer (see news release from SGO 2021 here). The pivotal study evaluated the combination of KEYTRUDA, Merck’s anti-PD-1 therapy, plus LENVIMA, the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai, versus chemotherapy (treatment of physician’s choice of doxorubicin or paclitaxel) for patients with advanced endometrial carcinoma following at least one prior platinum-based regimen in any setting. Merck (NYSE: MRK), known as MSD outside the United States and Canada, and Eisai today announced the publication of results from the Phase 3 KEYNOTE-775/Study 309 trial in the Januedition of the New England Journal of Medicine. ![]()
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6/29/2023 0 Comments Cat ii romanian linguist salary![]() Purpose: This IRM gives guidance for implementing the Language Services (LS) Program throughout the IRS. (9) Editorial changes made throughout the IRM, including: (8) IRM 22.31.1.7.5, Posting Content to the Multilingual Web Pages, changed the sentence to specify that translations are performed in the order they are received to clarify the intent of the sentence. (7) IRM 22.31.1.5.4.5 (7), Performing Quality Review of Translated Non-Vital Documents (third example), added “as well as a completed Form 14078” to acknowledge the requirement to include this form with SRS requests. (6) IRM 22.31.1.5.4.4 (4), Translating Non-Vital Documents (second example), added “as well as a completed Form 14078” to acknowledge the requirement to include this form with SRS requests. (5) IRM 22.31.1.5.1.1 (1), Requesting Translations of Non-Vital Documents from Certain Languages into English, removed the word “English” because translations are currently also performed from non-English languages into English. (4) IRM 22.31.1.5.1.1, Requesting Translations of Non-Vital Documents from Certain Languages into English, removed the phrase “from certain languages into English” from the title because, as written, it implies that translations are only done from non-English documents into English when, in fact, documents are also translated from English to certain non-English languages as well. (3) IRM 22.31.1.5.1 (1), Identifying the Document For Translation, deleted the word "certain" and added that translation from English to certain non-English languages may be requested, as this is a more accurate reflection of current processes. (2) IRM 22.31.1.2.2 (1) (b), Office of Equity, Diversity, and Inclusion (EDI) Civil Rights Unit (CRU) Strategic Process Responsibilities, deleted the responsibility to conduct pre- and post-award reviews as this is not one of CRU’s responsibilities. (1) IRM 22.31.1.1.5.1, Defined Terms, all examples were strengthened with more explicit descriptions. (1) This transmits revised IRM 22.31.1, Multilingual Initiative, IRS Language Services. IRS Language ServicesĢ2.31.1 IRS Language Services Manual Transmittal Taxpayer Education and Assistance Chapter 31. Exhibit 22.31.1-1 Languages Provided by LPTS Contractors.22.31.1.7.6 Maintaining the Multilingual Web Pages.22.31.1.7.5 Posting Content to the Multilingual Web Pages.22.31.1.7.4 Transmitting Content Submission Packages to the Linguistic Policy, Tools, and Services (LPTS) Section.22.31.1.7.3.1 Linguistic Policy, Tools, and Services (LPTS) Multilingual Web Page Content Manager.22.31.1.7 Multilingual Web Page Content Publishing Process.22.31.1.6.1 Timely Invoice Payment for OPI Service.22.31.1.6 Over-the-Phone Interpreter (OPI) Service.22.31.1.5.4.8 Recordkeeping of Translated and Reviewed Documents.22.31.1.5.4.7 Maintaining Translated and Reviewed Documents.22.31.1.5.4.6 Proofreading of Non-Vital Documents.22.31.1.5.4.5.1 Requesting Delivery Dates of Non-Vital Documents that Undergo Quality Review.22.31.1.5.4.5 Performing Quality Review of Translated Non-Vital Documents.22.31.1.5.4.4.1 Requesting Delivery Dates of Translated Non-Vital Documents.22.31.1.5.4.4 Translating Non-Vital Documents.22.31.1.5.4.3 Translating and Reviewing Vital Documents.22.31.1.5.4.2 Approving Documents for Translations.22.31.1.5.4 Processing a Translation Candidate.22.31.1.5.3 Evaluating the Organizational Impact of Translation.22.31.1.5.2.3 Adding a Statement to the English Version.22.31.1.5.2.2 Determining Alternatives to Translation.22.31.1.5.2.1 Determining Importance to Limited-English Proficient (LEP) Taxpayers.22.31.1.5.2 Determining the Candidacy of a Document for Translation.22.31.1.5.1.4 Identifying the Document Originator/Owner.22.31.1.5.1.3 Identifying the Language for Translation.22.31.1.5.1.2 Determining a Document is for Public Use. ![]() 22.31.1.5.1.1 Requesting Translations of Non-Vital Documents.22.31.1.5.1 Identifying the Document For Translation.22.31.1.5 Standard Translation Process (STP).22.31.1.4 Providing Language Assistance.22.31.1.3 Limited-English Proficient (LEP) Needs Assessment.22.31.1.2.3 Multilingual and Agency Services (MAS) Branch Strategic Process Responsibilities.22.31.1.2.2 Office of Equity, Diversity, and Inclusion (EDI) Civil Rights Unit (CRU) Strategic Process Responsibilities.22.31.1.2.1 Language Services Executive Advisory Council (LSEAC) Strategic Process Responsibilities.22.31.1.2 Limited-English Proficient (LEP) Strategic Process. ![]() 6/29/2023 0 Comments Tad hamilton![]() ![]() ![]() When the date goes better than expected, a love triangle forms between the girl, the celebrity, and the girl's best friend." 'Win a Date with Tad Hamilton!' is currently available to rent, purchase, or stream via subscription on DIRECTV, Microsoft Store, fuboTV, Google Play Movies, Amazon Video, AMC on Demand, Showtime, Vudu, Spectrum On Demand, YouTube, Showtime Amazon Channel, and Apple iTunes. Here's the plot: "A small-town girl wins a date with a Hollywood star through a contest. You probably already know what the movie's about, but just in case. Win A Date With Tad Hamilton opens with a movie within a movie: a cheesy 1940s-set romantic melodrama where everything is resolved with a single gesture. Released January 23rd, 2004, 'Win a Date with Tad Hamilton!' stars Kate Bosworth, Topher Grace, Josh Duhamel, Nathan Lane The PG-13 movie has a runtime of about 1 hr 35 min, and received a user score of 57 (out of 100) on TMDb, which put together reviews from 437 experienced users. ![]() Now, before we get into the nitty-gritty of how you can watch 'Win a Date with Tad Hamilton!' right now, here are some specifics about the DreamWorks Pictures romance flick. We've listed a number of streaming and cable services - including rental, purchase, and subscription options - along with the availability of 'Win a Date with Tad Hamilton!' on each platform when they are available. Unfortunately, the convention-endorsing climax suggests that might not have been intentional.Want to behold the glory that is ' Win a Date with Tad Hamilton!' in the comfort of your own home? Tracking down a streaming service to buy, rent, download, or view the Robert Luketic-directed movie via subscription can be difficult, so we here at Moviefone want to do right by you. His male leads daringly against type, Luketic manages to introduce an element of doubt and suspense to a genre that ran dry a long time ago. Plotwise, were in standard Some Kind Of Wonderful territory, so anyone familiar with that movie should know where were heading and whom we should be rooting for. ![]() And where Hamilton should be Tad The Cad, using Rosalee to improve his own life and career, newcomer Duhamel is instead utterly dashing, handsome, witty and charming sharing real chemistry with Bosworth. Grace, so good in That ∧0s Show, is here an uncomfortably caustic, charmless version of Chandler from Friends (with an appalling haircut that does him no favours in the heart-throb stakes) instead of demonstrating his love for Rosalee, hes reduced to taking snide pot-shots at his new love rival, Hamilton. However, thanks to some misjudged performances, that rapidly becomes dangerously lop-sided and irrevocably damages the movie. Its a neat set-up, but director Luketic quickly fades down the Tinseltown angle in favour of the love triangle. Which, fundamentally, boils down to her best friend, Pete (Grace), whos loved her from afar for years and Hamilton (Duhamel), a fast-living, hard-loving Hollywood star who sees Rosalee as his shot at redemption. On one side, we have the unwaveringly wholesome Rosalee (Bosworth, in a performance so sunny its little wonder theres a sub-plot devoted to her captivating array of smiles), a charming naïf so cute that everyone who meets her falls in love with her. Founding Pastors Dennis and Colleen Rouse began what was then known as Victory Christian Center in 1989 with a Bible study in their apartment home. Remember how surprised you were when Leia chose Han (although, with hindsight, all that icky incest business meant it was the only logical choice)? Well, Win A Date With Tad Hamilton is a valiant attempt to create a similar love triangle, but ends up getting all its sums wrong. Famous Hollywood actor Tad Hamilton (soap opera star Josh Duhamel making his film debut) is trying to promote his new movie. To work convincingly, every love triangle has to have three relatively equal parts, so that we, the audience, may believe that the outcome could legitimately go any way. Robert Luketic (Legally Blonde) directs the romantic comedy Win a Date With Tad Hamilton from a screenplay by TV scriptwriter Victor Levin. ![]() 6/29/2023 0 Comments Realistic angel drawing![]() Step 5: Finally, add the facial features of your gentle heavenly creature as shown above and some scalloped lines on her wings to give them some texture. Then, sketch the guardian’s hands in a praying position and draw in her feet. Step 4: Next, add the sleeve by drawing two straight lines going upward. Step 3: Sketch the wings by drawing a half-shaped heart with zigzag ends as big as the cherub’s body. ![]() Add the hair by sketching wavy lines on both sides of her face. Step 2: Next, illustrate the Angelic Ladies head by creating a heart-shaped face with a pointed end. Next, connect twos slightly slanted lines at the bottom and layer a partial square on top of that, to great the folds of her dress. then, connect the two lines by adding another curved line at the top. To do that, sketch two vertical curved lines. Step 1: First, let’s draw the body of the angel. Have fun creating some of these holy spiritual beings! ![]() You might find our Drawing Supplies for Beginners Post HEREuseful. But you can always draw over it with an ink Pen or marker when you are done, to define it some more. Kids or grown ups alike can follow these simple steps with this Angel Drawing guide! I would recommend creating your drawing with a pencil, as you can erase if you have any mistakes. Now let’s get drawing! For Non Commercial Use. Practice drawing these and then create a host of angels if you like! You can print out as many of the worksheets as you want to share with your Family, Sunday School Class, Classroom, Creative friends meet up, Senior Center and more. ![]() At the bottom of the post you will find a printable practice worksheet that you can print out, with some blank space included, so that you can practice right on the page. This fun lesson was scanned from a vintage children’s book in my collection. Today, let’s try Angel Drawing! In this post you will find step by step instructions for creating an Easy Angel drawing in just 5 steps. ![]() |